Abstract
To the Editor: We appreciate the opportunity to address several of the comments made by Nemoto and his colleagues1 regarding our prior work. First, and most importantly, we would like to emphasize that measurements of oxygen extraction fraction (OEF) remain the most rigorously validated method for identifying stroke risk in patients with carotid occlusion.2 We must disagree with statements by Nemoto et al that OEF is not predictive of stroke risk. This conclusion is not valid, as it is based on erroneous interpretation of our data. Increased OEF is predictive of stroke risk . The St. Louis Carotid Occlusion Study (STLCOS) was a blinded, prospective study of cerebral hemodynamics and stroke risk in patients with complete occlusion of a carotid artery.3 In this study, we prospectively set as a threshold the outer limits …
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