RE: Snake venom preparation for drug-resistant human immunodeficiency virus

Abstract

lettersRE: Snake venom preparation for drug-resistant human immunodeficiency virus Ramachandran Meenakshisundaram, Alagappan Uma, and Ponniah Thirumalaikolundu Subramanian Ramachandran Meenakshisundaram Institute of Internal Medicine, Madras Medical College, Chennai, India Search for more papers by this author , Alagappan Uma Institute of Microbiology, Madurai Medical College, Madurai, India Search for more papers by this author , and Ponniah Thirumalaikolundu Subramanian Institute of Internal Medicine, The Tamil Nadu Dr. M.G. Ramachandran Medical University, Chennai, India Search for more papers by this author Published Online:2 Apr 2009https://doi.org/10.4103/0256-4947.51791SectionsPDF ToolsAdd to favoritesDownload citationTrack citations ShareShare onFacebookTwitterLinked InRedditEmail AboutIntroductionTo the Editor:Recently the usefulness of snake venom preparation in the treatment of drug-resistant human immunodeficiency virus was demonstrated in clinical practice for the first time by Alrajhi and Almohaizeie.1 This represents an emerging concept in the era of anti-retroviral therapy (ART). The authors have reported that snake venom might have enhanced the activity of ART or independently through some of its components. With reference to mechanisms of action, other components of snake venom such as the sequence homology between venom and HIV-1 gp 1202 and protease3 might also have contributed to the enhanced activity of ART at different levels.ARTICLE REFERENCES:1. Alrajhi AA, Almohaizeie A. "Snake venom preparation for drug-resistant human immunodeficiency virus" . Ann Saudi Med. 2008; 28(4):292-293. Google Scholar2. Neri P, Bracci L, Rustici M, Santucci A. "Sequence homology between HIV gp120, rabies virus glycoprotein, and snake venom neurotoxins" . Archives of Virology. 1990; 114((3-4)):265-269. Google Scholar3. Simon CW, Philippe F, Olivier C, Gavin DL, Mark CW, Rebecca LM, Reto S, Robert AH. "Molecular characterization of endogenous snake venom metalloproteinase inhibitors" . Biochemical and biophysical research communications. 2008; 365(4):650-656. Google Scholar Previous article FiguresReferencesRelatedDetails Volume 29, Issue 2Mar–Apr 2009 Metrics History Published online2 April 2009 InformationCopyright © 2009, Annals of Saudi MedicineThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.PDF download