Re: Molecular pathology as a diagnostic aid in difficult to classify melanocytic tumours with spitzoid morphology: Melanocytic tumours with Spitz-like morphology: toward a therapy-oriented diagnostic approach

Abstract

Zaremba et al. [1] have recently proposed a case-based approach to melanocytic tumours with ‘Spitz-like’ (cyto)morphology. Of the cases presented, two were ultimately diagnosed as ‘classical’ (spitzoid) melanoma because of harbouring melanoma-specific driver mutations (BRAF V00E in Case 1; NRAS Q61R in Case 3; both cases also disclosing additional TERT promoter mutation); the other two cases lacked any classical melanoma mutation, but were addressed to a management as per melanoma because of their striking histopathological features of atypia (allegedly, melanocytic tumours of uncertain malignant potential; MEL.T.U.M.P.).