Re: “Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations”

Abstract

In a recent paper, Casey et al. report that after prophylactic oophorectomy intra-abdominal carcinomatosis occurred in five of 122 BRCA1 or BRCA2 mutation carriers. They argue that these events may result from dissemination of occult tumors [1]. Hogg et al. (2004) suggest that stage I ovarian carcinomas are biologically different from advanced stage carcinomas. Two separate models were proposed for the development and progression of epithelial ovarian carcinoma. In the first model, well-differentiated serous and other epithelial carcinomas are included.