Re-analysis of data from a cluster RCT entitled "health literacy and exercise-focused interventions on clinical measurements in Chinese diabetes patients".

Abstract

Wang et al.1 examined the effects of three health literacy and exercise interventions on HbA1c (the primary outcome) in a four-arm cluster randomized trial (cRCT), but did not account for clustering and nesting. Eight Healthcare Centers (CHCs) were randomly assigned to four conditions (two per condition). Repeated measurements occurred at four timepoints after enrollment. Nominally significant p-values were reported for intervention effects on HbA1c. We reanalyzed the data accounting for clustering and nesting, and present the results herein.