Abstract
In 1862, Raynaud first described, as a completely independent nosological unit, a kind of disease of the peripheral and most protruding parts of the body (fingers of the upper and lower extremities, auricles, the tip of the nose, cheeks), now known under the name of Raynaud's symmetric gangrene ... Since that time, little new has been introduced into the etiology and pathogenesis of this disease.
Published Version
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