Abstract
Silymarin is a natural antioxidant polyphenolic flavonoid structure, it has been reported to be effective against free radicals and reactive oxygen species. Indomethacin is a nonsteroidal anti-inflammatory drug and can promote ulcer in gastric tissue. The purpose of this study was to investigate the protective effects of silymarin on indomethacin-induced gastric ulcer model. Forty two male Wistar albino rats were divided into 6 groups (n=7); control, indomethacin, lansoprazole+indomethacin, silymarin (25, 50 and 100 mg/kg)+indomethacin group. Different doses of silymarin were administered by oral gavage and then gastric ulcers were induced by oral administration of indomethacin (25 mg/kg). Ulcer protective activity of silymarin was compared with lansoprazole (30 mg/kg). The rats were euthanized 6 h after indomethacin exposure. Activities of superoxide dismutase (SOD), catalase (CAT) and myeloperoxidase (MPO) as well as malondialdehyde (MDA) and glutathione (GSH) levels were determined in stomach tissue. Gastric tissue was also assessed in terms of macroscopic as ulcerative areas. As a result, 100 mg/kg silymarin was showed antiulceratif effects. The same dose of silymarin significantly decreased MDA level and MPO activity, and increased SOD activity and GSH level in stomach tissue. Silymarin might have a protective effect against indomethacin-induced gastric ulcer as well as oxidative stress in rat.
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