Abstract
Pain is the main symptom of most of rheumatic conditions. In many cases, analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs) or opioids control pain effectively. However, in some cases, additional treatments such as antidepressants and anticonvulsants are required [1]. Although antidepressants have been used as analgesics drugs for more than 40 years, they have only recently been approved for analgesic use, and only in neuropathic pain [2]. In the meantime, although they have become common drugs for the management of chronic pain, many issues still remain to be elucidated, especially in rheumatology. To explore the relevant use of antidepressants in rheumatic conditions, a task force from the French Society of Rheumatology Comprehensive Epidemiologic Data Resource (CEDR) was established. The literature review was based on 137 relevant papers, 99 selected for detailed analysis, 77 randomized controlled studies and 12 meta-analyses or literature review.
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