Abstract
AbstractAn unusual solvent‐induced inversion of the sense of enantioselectivity observed in the α‐selenylation of aldehydes catalyzed by a diphenylprolinol silyl ether catalyst is correlated to the presence of intermediates formed subsequent to the highly selective CSe bond‐forming step in the catalytic cycle. This work provides support for a mechanistic concept for enamine catalysis and includes a general role for “downstream intermediates” in selectivity outcomes in organocatalysis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have