RATIONALE OF THE COMPOSITION OF THE TABLET MASS FOR THE CREATION OF DISPERSIBLE TABLETS WITH BIOFLAVONOIDS

Abstract

Abstract. In recent years, with diseases associated with chronic venous insufficiency, people have resorted to medications created on the basis of bioflavonoids and flavonoid complexes. However, most oral phleboprotectors, including flavonoids such as rutin, hesperidin, diosmin, have low biological availability, which is due to their low solubility in water. It is possible to increase bioavailability by using substances with a higher degree of micronization, as well as by complexing and using dosage forms with increased bioavailability. In this regard, the purpose of this work was to create a drug in the form of dispersible tablets containing rutin and hesperidin in combination with ascorbic acid as active components. Substances of rutin and hesperidin, ascorbic acid, a PE-5300V spectrophotometer, a stopwatch, scales, buckets, a manual press with pressure gauges of various sensitivity, a tablet press RTM-12, punches and a matrix with a diameter of 10 and 20 mm were used in the work. To determine the main indicators of tablet mixtures for dispersible tablets, 6 model compositions of tablet mixtures with different contents of gas-forming components, fillers, binders, moisture stabilizers, lubricants and flavor additives were made. In the course of a step-by-step study of technological, physico-chemical and organoleptic indicators of 6 model formulations, the approximate composition and technology of dispersible tablets were selected. The obtained results were recalculated taking into account the ranking of the measurements made. The integrated weighted average assessment of disintegration, crushing strength, ejection pressure, moisture resistance, organoleptic properties and sedimentation stability made it possible to select the final composition of the dispersed tablets. It is established that the maximum weighted average score belongs to the dispersed tablets obtained from tablet mixture No. 6.