Abstract
As outlined in Chapter 1 definite advantages were realized with the use of “fresh” wet-stored antibiotic-sterilized human homograft valves for the reconstruction of left and right ventricular outflow tracts. However, problems with availability and lack of certainty concerning preservation and storage techniques limited their widespread use. The combination of their resistance to infection, excellent hydraulic function, absence of need for anticoagulation, and versatility in difficult outflow reconstructions made them optimal choices for many categories of patients— beyond the single issue of durability. The durability of the nonviable but gently preserved homografts was certainly as good as xenografts in adults and even better than xenografts in children. If durability could be improved, a homo- graft would combine the superior attributes of xenografts with the superior attributes of mechanical prostheses and thus be the valve of choice.
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