Rational synthesis of graphene–metal coordination polymer composite nanosheet as enhanced materials for electrochemical biosensing

Abstract

The designed synthesis of graphene-based nanocomposites for enhancing their different potential application is of great interest recently. In this paper, we demonstrated a new class of high-quality graphene-based nanocomposites: metal coordination polymer–graphene nanosheets (MCPGNs). The as-obtained nanocomposite, combining the unique properties of graphene (excellent conductivity and high specific surface area) and MCPs (tunable pore size, large internal surface areas and versatility of functionality), can act as an efficient matrix to immobilize glucose oxidase (GOD). Furthermore, the as-prepared MCPGNs exhibit better conductivity and electrocatalytic activity for H2O2 reduction than graphene. Based on these excellent properties, a sensitive electrochemical biosensing platform for glucose was fabricated. This novel biosensor displays a linear response range between 50 nM and 1 mM with a detection limit of 5 nM. Our work not only provides a facile, effective and general route for the synthesis of a variety of MCP–graphene nanohybrids, but also sets an example for fabricating an electrochemical biosensor with this new kind of nanohybrid as an enhanced material and can be easily extended to other biosensors. These interesting results suggested the great potential of MCP–graphene nanocomposites in the field of electroanalytical chemistry.