Rational Renometrics

Abstract

The precise evaluation of renal function and structure is indispensable clinical medicine. This is required not only to screen,diagnose and monitor kidney disease, but also to allow accurate choice of drugs and their dosages while treating individuals.Traditional methods, exemplified by glomerular filtration rate (GFR) calculations and urinalysis, have long served as pillarsof nephrology. However, their inherent limitations introduce diagnostic ambiguities, raising concerns for both health careproviders and patients. This comprehensive review introduces the concept of "Rational Renometrics", a transformativeapproach that harmonizes various tests and factors to provide a holistic assessment of renal health. It focuses on correcturine sample collection, mitigates false positives in urinalysis and embraces the concept of permissive hypercreatinemia.The evidence-based, data-driven perspective of rational renometrics empowers health care providers and patients, leadingto more accurate diagnoses, individualized treatment strategies and improved therapeutic outcomes. Rational renometricsallows accurate risk assessment and institution of preventive interventions, reinforcing its pivotal role in preserving renalhealth and optimizing patient care. We describe the principles, advantages, challenges and potential clinical applications ofrational renometrics, emphasizing the need for continued research and validation of this concept.