Abstract
Drug-induced liver injury (DILI) has become a common adverse effect in routine clinical practice, which would further cause the disorder of enzymatic system that respond to multiple pathological progresses. Leucine aminopeptidase (LAP) is regarded as a biomarker in the early course of various liver diseases, in this work, a fluorescent probe NCPL was designed and synthesized for the detecting of LAP. NCPL possessed excellent properties including high selectivity, sensitivity and affinity toward LAP, it could real-time image the LAP activity in living cells and tissues. Additionally, the upregulation of LAP under the APAP-induced liver injury model was also illustrated by NCPL. In conclusion, NCPL as a novel tool could be used for the detection of LAP and monitoring liver function in clinic.
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