Ratio of dopamine, hormones, autoantibodies of the pituitary-thyroid body and regimen factorsin the indigenous population of Yamal

Abstract

The aim is to study the problem of the actual nutrition effect on the state of the pituitary-thyroid body in the indigenous population of the Yamalo-Nenets Autonomous District in connection with the change of traditional nutrition and the deteriorating environmental situation. Methods. 212 inhabitants (aged 21-50 years old) were surveyed, among them 63 - representatives of tundra and 149 -settlement population. The levels of hormones, autoantibodies, dopamine, cyclic adenosine monophosphate (cAMP) were determined by immunoenzyme and radioisotope methods in serum and plasma. The absolute values of the actual magnitudes of the daily average diet, the medians of the indicators, the percentages of their deviations from the reference limits, the Spearman's correlation coefficients were calculated. Results. The tundra population in comparison with the settlement is characterized by a lower content of free thyroxine, an integral thyroid index against the background of higher levels of thyrotropine and thyreoglobulin with lowering levels of antibodies to thyroglobulin. In the tundra population, the daily intake of deer's blood, broad whitefish, butter, macaroni and flour is higher, while in the settlement - chicken, cheese, and apples. In the tundra population, positive correlations with cAMP content were revealed with the consumption of broad whitefish, vendace, local berries, carrots, onions, vegetable oil and negative - with the consumption of smoked sausage and tea. Consumption of pike, smelt negatively correlated with the content of total and free thyroxine fractions. Negative links were found between the amount of broad whitefish consumption and the thyroglobulin content, and the antibodies content to thyroglobulin and thyroperoxidase - positive. Conclusions. The thyroid status and feeding habits in tundra and settlement indigenous people are different. Traditional foods are positively correlated with cAMP content. The consumption of local fish negatively correlates with the content of thyroglobulin, iodothyronines and positively with the levels of autoantibodies.