RATIO NIGHT/DAY OF BLOOD PRESSURE AS A MARKER OF INJURY ATHEROSCLEROTIC VASCULAR: PP.31.251

Abstract

Objective: To analyze the relationship between ratio night/day of systolic blood pressure and arterial stiffness assessed with carotid intima-media thickness, pulse wave velocity and Augmentation Index. Methods: Design: Cross-sectional study. Setting and Participants: 262 hypertensive patients < 75 years included by consecutive sampling. Average age 54.96 ± 11.58 years, 61.5% males. Measurements: Monitoring ambulatory blood pressure (BP) of 24 hours and estimate systolic and diastolic ratio night/day. Pulse wave velocity (PWV), central blood pressure and Augmentation index (AIx) measured with the SphygmoCor System. Carotid intima-media thickness (IMT) measured with ultrasound. Results: The mean awake BP were 129.45/79.85 mmHg and asleep BP 114.26/66.30 mmHg. IMT mean was 0.74 ± 0.12 mm, and the maximum mean 0.91 ± 0.14 mm. PWV was 9.09 ± 2.21 m/sec. Increase aortic pressure was 14.16 ± 8.82 mmHg, Central pulse pressure (PP) 43.83 ± 13.66 mmHg, Central AIx 30.57 ± 13.30, Central AIx adjusted FC 75 l/m 28.95 ± 11.18 and Peripheral AIx 92.49 ± 21.13. We found positive correlation of systolic ratio night/day with IMT mean (r = 0.268, p = 0.000), IMT maximum mean (r = 0.279, p = 0.000), PWV (r = 0.226, p = 0.000), aortic PP (r = 0.281, p = 0.000), increased central blood pressure (r = 0.234, P = 0.000) and central AIx (0.153, p = 0.013). In multiple linear regression (Stepwise) after adjusting for age, sex and antihypertensive drugs, and considering as dependent variable the ratio night / day, persists in equation, central PP and IMT maximum mean. Conclusions: Ratio night/day of systolic blood pressure was positively associated with markers of arterial stiffness and could be a predictor of atherosclerotic vascular injury.