Rathke’s Cleft Cyst Presented with Central Diabetes Insipidus in a Young Female

Abstract

Rathke’s cleft cyst (RCC) is a benign lesion originating from remnant of Rathke’s pouch. RCC presenting as diabetes insipidus is rare. Here we present a case of a 32 year young female presented to our outpatient department with history of polyuria, polydipsia, nocturia with preference to cold liquids and diffuse mild to moderate intensity headache for last 2 months. On investigation, she was found to have partial central diabetes insipidus without other pituitary hormone deficiency. Magnetic resonance imaging (MRI) of sellar region was done which revealed Rathke’s cleft cyst with deviation of the infundibulum and loss of posterior pituitary bright spot. Patient was given a trial of oral desmopressin, and within 2 days patient responded with reduction of urine volume.