Abstract

Rathke cleft cyst is thought to arise from incomplete obliteration of the lumen of Rathke pouch. The cells of the anterior pituitary lobe, from which pituitary adenomas develop, are also derived from the cells of Rathke pouch. Although Rathke cleft cyst and pituitary adenoma have a shared ancestry, they rarely occur coincidentally. Rathke cleft cysts have been found incidentally in 11% - 33% of post-mortem examinations, and were associated with 1.7% - 2.1% of the pituitary adenoma cases. These coexisting lesions are difficult to diagnose pre-operatively due to the variable signal intensity and position of the Rathke cleft cysts. Treatment of these lesions involves surgical resection to decrease mass effect and medical management to normalize hormonal imbalances. To our best knowledge, only 42 cases of Rathke cleft cyst with a coexisting pituitary adenoma have been reported in the English or Japanese literatures, but none of the coexisting pituitary adenoma is gonadotropin producing. We would like to report a case of Rathke cleft cyst with a coexisting gonadotropin producing adenoma that was successfully treated by endoscopic endonasal transsphenoidal approach with the removal of the sellar lesion and temporary hormone replacement.

Highlights

  • Rathke cleft cyst (RCC), first described by Luschka in 1860 [1] [2], is thought to arise from incomplete obliteration of the lumen of Rathke pouch

  • We would like to present a case of Rathke cleft cyst with a coexisting gonadotropin producing adenoma which probably is the first reported combination

  • In cases of symptomatic Rathke cleft cyst, the common symptoms are headache, visual disorder, endocrine dysfunction probably caused by the mass effect on the adjacent structures [1] [2] [4] [7] [8]

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Summary

Introduction

Rathke cleft cyst (RCC), first described by Luschka in 1860 [1] [2], is thought to arise from incomplete obliteration of the lumen of Rathke pouch. This embryonic structure develops as a rostral outpouching of the stomodeum or. (2015) Rathke Cleft Cyst with a Coexisting Gonadotropin Producing Pituitary Adenoma. Primitive oral cavity during the third or fourth week of gestation It has an anterior and posterior wall, as well as a central embryonic cleft. We would like to present a case of Rathke cleft cyst with a coexisting gonadotropin producing adenoma which probably is the first reported combination

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