Rates of preeclampsia in subsequent pregnancies by race/ethnicity

Abstract

To assess whether race/ethnicity impacts rates of preeclampsia amongst pregnant persons with a history of preeclampsia in the previous pregnancy. A retrospective cohort study of two consecutive births in California between 2000-2012 among pregnant persons who had a history of preeclampsia in the index pregnancy. We included singleton, non-anomalous index pregnancies from gestational ages 23-42 weeks. We assessed rates of preeclampsia in the second pregnancy by race/ethnicity, age, BMI, educational attainment and insurance type in chi-squared analysis. We conducted a multivariable logistic regression for repeat cases of preeclampsia by race/ethnicity adjusting for pre-pregnancy BMI, age, education, and insurance type as potential confounders. Race/Ethnicity was stratified into patients who identified as Non-Hispanic White, Non-Hispanic Black, Non-Hispanic Asian, Hispanic, American Indian/American Native (Non-Hispanic), and Other. There were 22,096 births that met our inclusion criteria. Of those, 3,908 had preeclampsia in the subsequent pregnancy. Of those with preeclampsia in the second pregnancy, the majority (47%) identified as Hispanic, as did the majority of those without preeclampsia in the second pregnancy (49%). The rest of the populations racial/ethnic makeup were comparable. In our multivariable regression, compared to patients who identified as Non-Hispanic White, there were no significant difference in odds of having preeclampsia again in a subsequent pregnancy by race/ethnicity. Among patients who have had preeclampsia in a prior pregnancy, there were no significant differences in odds of having preeclampsia in the subsequent pregnancy by race/ethnicity.View Large Image Figure ViewerDownload Hi-res image Download (PPT)