Abstract
The mean time of unwinding of a DNA molecule is calculated. The unwinding is assumed to begin at one end and to proceed under the combined forces of diffusion and a driving torque of arbitrary magnitude. The standard deviation of the unwinding time is calculated approximately. If the free energy decrease on unwinding one turn, in units of kT , times the number of turns in the molecule is a number much greater than unity, diffusion plays a negligible role in the unwinding.
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