Rate of colorectal neoplasia in patients with Hodgkin lymphoma

Abstract

Survivors of Hodgkin lymphoma (HL) are at increased risk of breast, lung, thyroid, stomach, pancreatic and colon cancer. There is limited information on the utility of endoscopic screening for colon cancer. We aimed to describe the adenoma detection rate (ADR) in patients with HL to determine the appropriate timing of colonoscopy screening. We retrospectively studied patients with HL who underwent colonoscopy between 2000 and 2017. A total of 251 patients underwent colonoscopy. Eighty (32%) patients had 151 colonic polyps. Thirty per cent of the polyps exhibited high-grade dysplasia, and invasive colon adenocarcinoma was found in 10 patients. Patients with the nodular sclerosing subtype of HL had a significantly lower ADR than others (P=0.002). The ADR was 5% in patients younger than 35years (n=64), 23% in patients between 35 and 40years of age (n=22), 39% in patients between 40 and 50years of age (n=51) and 46% in patients older than 50years (n=114).