Abstract
The behavioural effects of 1.0, 3.10 and 6.0 mg/kg imipramine injections on lever pressing of rats were studied. Lever pressing was reinforced according to a continuous reinforcement schedule at 0, 24, and 48 h of water deprivation, according to fixed ratio schedules with 22 1/2 h of water deprivation, and according to differential‐reinforcement‐of‐low‐rate schedules with 22 1/2 h of water deprivation. The mean rate of responding per min increased significantly at 1.0 mg/kg on the continuous reinforcement schedule at 24 h of deprivation. Otherwise, a dose‐related significant reduction in the mean response rate per min occurred on the fixed raito schedules and partly on the differential‐reinforcement‐of‐low‐rate schedules, thus lending support to the idea that rate dependent effects may be produced only on schedules of reinforcement such as the fixed ratio, the fixed interval and the variable interval. The results also indicate that depenent effects may be produced only at moderate levels of water deprivation. Some critical comments are made on concepts of rate dependency in view of the results and of previous finding.
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