Abstract
Rat extralobar pulmonary artery responses to some anaphylactic mediators and arachidonic acid metabolites were studied on “in vitro”. Histamine (H), serotonin (5HT), bradykinin (Bk) and norepinephrine (NE) contract the pulmonary arteries ; all the arachidonic acid metabolites tested (PGE 2 - PGF 2α - PGI 2 - LTC 4) also exert a vasocontractile activity and among these PGF 2α is the most active whereas LTC 4 exerts only a weak effect. Isoproterenol, papaverine and adenosine weakly relax the vascular preparation, while acetylcholine and PAF-acether have no effect. The interference of indomethacin on NE-5HT-H-induced contractions has been investigated. Indomethacin reduced the contractile activity of H while the cyclo-oxygenase inhibitor did not significantly interfere with the effect of NE and 5HT. The possible relationships between some anaphylactic mediators and the arachidonic acid metabolites have been discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
