Abstract
Rat Models of Spinal Cord Injury Provide Valuable Insight to Understand the Mechanism and Pathophysiology of Spinal Cord Injury
Highlights
NorCal Open Access PublicationsCord, a primary or mechanical injury and a secondary injury process
Phases of Spinal Cord InjuryThe spinal cord contains neural circuitry and motoneurons in the There are two mechanisms by which SCI damages the spinalNorCal Open Access PublicationsCitation: Hassan A (2018) Rat Models of Spinal Cord Injury Provide Valuable Insight to Understand the Mechanism and Pathophysiology of Spinal Cord Injury
A variety of animal models including dogs, cats, guinea pig, primates and rodents have been developed to examine the mechanisms, pathophysiology and functional deficits following SCI, and to test intervention strategies to develop effective therapies for the treatment of SCI. Rodents, such as rats and mice, have emerged as the main animal used in Spinal Cord Injury research, making up 90% of laboratory animals used in SCI research [41]
Summary
Cord, a primary or mechanical injury and a secondary injury process. Secondary damage is mediated through multiple processes, including inflammation, apoptotic cell death, excitotoxicity within the first week following SCI, causing further destruction of neuronal and non-neuronal cells [9]. The identification and understanding of mechanisms which initiate and sustain the inflammatory response, apoptosis, excitotoxicity, could help us to develop new treatment strategies which prevent or reduce this secondary damage and improve functional recovery [11]. These primary and secondary mechanisms of spinal cord damage are described in more detail below
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