Rat Model of Empathy for Pain.

Abstract

Empathy for pain is referred to as an evolutionary behavior of social animals and humans associated with the ability to feel, recognize, understand and share the other's distressing (pain, social rejection and catastrophe) states. Impairment of empathy can definitely lead to deficits in social communication and sociability (attachment, bond, reciprocity, altruism and morality) that may be fundamental to some psychiatric disorders such as autism spectrum disorder (ASD), psychopathy, misconduct, antisocial personality disorder and schizophrenia. So far, the underlying mechanisms of empathy are poorly known due to lack of animal models and scarce understanding of its biological basis. Recently, we have successfully identified and validated the behavioral identities of empathy for pain in rats that can be widely used as a rodent model for studying the underlying biological mechanisms of empathy. Priming dyadic social interaction between a naive cagemate observer (CO) and a cagemate demonstrator (CD), rather than a non-cagemate, in pain for 30 min in a testing box can repeatedly and constantly result in empathic responses of the CO toward the familiar CD's distressing condition, displaying as allo-licking at the injury site, allo-grooming at the body and social transfer of pain. The familiarity-based, distress-specific social consolation and subsequent social transfer of pain can be qualitatively and quantitatively rated as experimental biomarkers for empathy for pain. The rodent model of empathy for pain is state-of-the-art and has more advantages than the existing ones used for social neuroscience since it can reflect sensory, emotional and cognitive processes of the brain in running the prosocial and altruistic behaviors in animals who could not report verbally. Here we would like to provide and share the protocol of the model for wide use.