Abstract
1. 1. Malate-dependent swelling of lung mitochondrial preparations in iso-osmotic ammonium citrate, and the inhibition of citrate formation by n-butylmalonate and benzene 1, 2, 3-tricarboxylate. suggest the presence of a malate-citrate exchange diffusion mechanism in lung mitochondria. 2. 2. d-Malate and 2-hydroxymalonate stimulated citrate formation from pyruvate and 2-oxoglutarate, suggesting that the presence of a suitable counter-ion for citrate efflux is a significant factor in the determination of extramitochondrial citrate availability. 3. 3. ADP-stimulated rates of pyruvate oxidation and citrate formation were inhibited by atractyloside. indicating the presence of the adenine nucleotide translocating system in lung tissue. 4. 4. Palmitoyl-CoA was found to inhibit citrate formation in lung mitochondrial preparations, presumably by an effect on the citrate translocator.
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