Abstract

Rat liver microsomal monooxygenases transform ethene to oxirane. Compared with 1,3-butadiene, which is metabolized to vinyl oxirane, this transformation proceeds more slowly. Also, oxirane has a distinctly lower alkylating potency than vinyloxirane towards the test reagent ( p-nitrobenzyl)-pyridine. This may suggest a lower toxicity of ethene, compared with butadiene.

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