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Abstract
Rat liver arginase system under acetaminophen-induced toxic injury and protein deprivation
Highlights
Protein deficiency becomes quiet common at present due to a constant increase of carbohydrates and fats content in a ration combined with the reduction of protein content or replacement of a full-value dietary protein with a low-value soya protein [1]; vegetarianism, dietary restrictions in different diseases, irrational artificial feeding [2]
The animals were divided into the following experimental groups: I – animals maintained on the full-value semisynthetic ration balanced by all nutrients – control group (C) [22]; II – animals maintained on the semisynthetic low-protein ration (1/3 of the commonly accepted daily protein requirements) (LPR) [23]; III – animals subjected to acetaminophen-induced liver lesions receiving complete ration (H) (TI); IV – animals subjected to acetaminophen-induced liver lesions that were previously fed semi-synthetic lowprotein ration (LPR+H)
Intracellular arginases compartmentalization plays an important role in the metabolism of L-arginine
Summary
Protein deficiency becomes quiet common at present due to a constant increase of carbohydrates and fats content in a ration combined with the reduction of protein content or replacement of a full-value dietary protein with a low-value soya protein [1]; vegetarianism, dietary restrictions in different diseases, irrational artificial feeding [2]. The aim of current research was to study the arginase activity and L-arginine content in both mitochondrial and cytosolic liver fractions under the conditions of toxic injury against the background of protein deficiency. L-arginine content in cytosolic and mitochondrial fractions was determined by the method of [26] after precipitation of proteins with 20% TCA solution.
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