Abstract
Hsp20 is a mammalian small heat shock protein with some deviatingin vitrocharacteristics. We now compare thein vivocellular thermoprotective abilities of Hsp20 with those of its direct relative, αB-crystallin. In a clonal survival assay Chinese hamster ovary (CHO) cells stably overexpressing Hsp20 survive equally well as αB-crystallin-expressing cells, after a heat shock. In a transient assay, however, overexpression of Hsp20 did not result in an enhanced recovery of coexpressed firefly luciferase after heat shock, in contrast to αB-crystallin. This might indicate that these highly homologous stress proteins are involved in at least partially distinct protective activities in cultured cells.
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