Abstract
Abstract The in vitro and in vivo longitudinal (T1) and transversal (T2) relaxation times of the singlet resonances of the three major metabolites: N-acetylaspartate, creatine and choline, in healthy rat brains were estimated at 4.7 T and 7 T. Field-dependent variations in the T1 and T2 relaxation time values were observed with high significance, since the measurements were performed under near-identical experimental conditions. The longitudinal/transverse relaxation times exhibited an increase/decrease with increasing magnetic field strength. The metabolite relaxation time estimates, presented in this study, are useful for optimizing measurement protocols and for improving the quantification of proton magnetic resonance spectroscopy signals, in order to perform T1 and T2 effect corrections for absolute quantification of brain metabolites.
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