Abstract
Intracisternal 6-hydroxydopamine in rats pretreated with pargyline causes a marked decrease in levels of 3,4-dihydroxyphenylalanine decarboxylase in upper and lower brain stem regions 7 days post-treatment. Fifteen days after treatment with 6-hydroxydopamine, similar changes are noted in cortical areas as well. This loss of 3,4-dihydroxyphenylalanine decarboxylase activity does not temporally coincide with morphologic degeneration of nerve endings or catecholamine depletion in the various regions. 5-Hydroxytryptophan decarboxylase activity, determined on the same regional tissue, did not decrease, and even increased significantly in hypothalamus, cerebellum, and lateral medulla-pons. The disparate loss in 3,4-dihydroxyphenylalanine decarboxylase activity without corresponding loss in 5-hydroxytryptophan decarboxylase activity suggests that the two decarboxylase activities in brain tissue are catalyzed by separate, distinct proteins.
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