Abstract
In order to explore the association between RASSF1A methylation and nasopharyngeal carcinoma (NPC) risk of Chinese, we carried out a meta-analysis with searches of PubMed, Web of Science, ProQest and Medline databases. Ultimately, 14 articles were identified and analysised using R Software (R version 3.1.2) including meta packages. Overall, we found a significant relationship between RASSF1A methylation and NPC risk (OR 30.7; 95 % CI, 16.71~56.23; z=11.0591; p<0.0001) in a fixed effects model and (OR 32.1; 95% CI, 14.27~72.01; z=8.3984; p<0.0001) in a random effects model pooled. In tissue and NP brushings groups , similar results were found. Hence, our study identified a strong association between RASSF1A methylation and NPC and highlighted a promising potential for RASSF1A methylation in NPC risk prediction of Chinese.
Highlights
Nasopharyngeal cancer (NPC) is a prevalent human malignancy in Southern China and Southeast Asia
We found a significant relationship between Ras association domain family 1A (RASSF1A) methylation and nasopharyngeal carcinoma (NPC) risk in a fixed effects model and in a random effects model pooled
NPC is generally only diagnosed at advanced stages of cancer progression because of its location deep inside the head and its vague symptoms which leading to poor prognosis and low survival rate of patients (Xie et al, 2014)
Summary
Nasopharyngeal cancer (NPC) is a prevalent human malignancy in Southern China and Southeast Asia According to the data from the International Agency for Research on Cancer, the incidence rate of NPC is 20-50 per 100,000 in Southern China, while it is only 1 per 100,000 in most parts of the world. Nasopharyngeal carcinoma is a distinct type of head and neck cancer and is very different from other head and neck cancers because of its specific multifactorial etiology and its geographic distribution. The molecular basis of NPC pathogenesis is not well understood, but is believed to involve a multistep process including Epstein-Barr Virus (EBV) infection, environmental factors, as well as genetic and epigenetic alterations (Tao and Chan, 2007). The development of biomarkers for effective early diagnosis of NPC is clearly necessary
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