Abstract
The epithelial-mesenchymal transition (EMT) has been implicated in cancer invasion and metastasis. Depending on the cellular context, oncogenic Ras can induce EMT in the presence of transforming growth factor-b (TGF-b). By synergistically promoting the EMT in cooperation with TGF-b, oncogenic Ras promotes cell migration in vitro and tumor invasion and metastasis in vivo . Despite these observations, the mechanism by which oncogenic Ras contributes to the EMT is not well understood. We recently demonstrated that BLT2, a G protein-coupled receptor for the inflammatory lipid mediator leukotriene B 4 (LTB 4 ), lies downstream of Ras and mediates oncogenic Ras-induced EMT in mammary epithelial cells. Thus, these inextricable networks involving the Ras oncogene, EMT and inflammatory lipid mediators play critical roles in the tumor microenvironment.
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