Abstract
(The American Journal of Human Genetics 94, 574–585; April 3, 2014) The following sentence was omitted from the Acknowledgments statement: this work was supported, in part, by British Heart Foundation Grants PG/07/045 and CH/09/003. Additinally, David F. FitzPatrick should have been David R. Fitzpatrick, as it appears here. The authors regret these oversights. Rare Variants in NR2F2 Cause Congenital Heart Defects in HumansAl Turki et al.The American Journal of Human GeneticsApril 03, 2014In BriefCongenital heart defects (CHDs) are the most common birth defect worldwide and are a leading cause of neonatal mortality. Nonsyndromic atrioventricular septal defects (AVSDs) are an important subtype of CHDs for which the genetic architecture is poorly understood. We performed exome sequencing in 13 parent-offspring trios and 112 unrelated individuals with nonsyndromic AVSDs and identified five rare missense variants (two of which arose de novo) in the highly conserved gene NR2F2, a very significant enrichment (p = 7.7 × 10−7) compared to 5,194 control subjects. Full-Text PDF Open Access
Highlights
In this article, the derivation of the likelihood function (Equation 11) is incorrect
the model is for the set of summary statistics
All errors were in the exposition
Summary
The derivation of the likelihood function (Equation 11) is incorrect.
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