Abstract
Rare Rotavirus Strains in Children with Severe Diarrhea, Malaysia
Highlights
To the Editor: We report the identification of G3P[9] rotavirus in children with acute diarrhea in Malaysia
Phylogenetic analysis was conducted by using MEGA version 4.1 and neighbor-joining method with 1,000 bootstrap replicates (10).The 4 G3P[9] rotavirus strains all exhibited identical nucleotide and amino acid sequences for the regions of VP7 and VP8 subunit of VP4 analyzed
Phylogenetic analysis of the VP7 nucleotide sequence revealed that the Malaysian G3P[9] strain (552157) clustered with animal G3 strains and human G3P[9] strains from various countries but was distinct from G3P[8] strains causing disease in children in Malaysia over the same period (Figure, panel A)
Summary
Neck rigidity (2 patients) were observed. Signs and symptoms at the time of hospitalization and at followup for 6 months (at 3-month intervals) were similar for persons infected with JEV and those infected with WNV. The finding indicates that WNV might be the cause of a substantial number of acute encephalitis syndrome cases in this region. Identification of circulating genotypes of WNV and its vectors and epidemiologic studies are needed to obtain additional information on WNV infection in this region and identify WNV as a cause of acute encephalitis syndrome.
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