Abstract
Systemic Lupus Erythematosus is a clinically heterogeneous autoimmune disease of complex etiology, with protein manifestations, having a variable course and prognosis. It effects primarily women in their childbearing years (20-40 years). We reported a rare case of 23-year-old woman presented to the GIT clinic with long history (more than 18-months) of hemoptysis without any other significant symptoms and signs. Physical examination reveals tachycardia, and normal blood pressure. Ventilation perfusion scanning is normal. Investigation excluded infectious etiology. Immunological markers revealed high titre of antinuclear antibody (ANA), normal dsDNA antibodies and anti SM. All the imaging investigation are normal including OGD. A cyclophosphamide and methylprednisolone pulses were started, with good initial response. In unusual SLE presentation, a wide range of differential diagnosis has to be considered. Primary SLE presents difficult diagnostic and therapeutic approach. Keywords: Systemic Lupus Erythematosus; Hemoptysis; Antinuclear antibody (ANA)
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