Abstract
The purpose of this study was to determine the clinicopathological and immunohistochemical features of lipoma/fibrolipoma with rare occasions as osseous and/or chondroid differentiation in the oral cavity. Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied. These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively. Immunohistochemical study revealed that peripheral spindle cells around chondroid tissue stained diffusely for S-100 α & β and Sox-9, though peripheral spindle cells around osteoid tissue only stained for RUNX-2. According to review of the literature, lipoma/fibrolipoma with osseous and/or chondroid differentiation was 18 cases. Also fibrolipoma with osseous and chondroid differentiation is the first to be reported here. These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.
Highlights
Lipomas represent uncommon neoplasms of the oral cavity; only 1% to 5% of cases occur at this site [1]
Based on their histopathological features of conspicuous multiple components, lipomas can be divided into some subclasses [2, 3], and the most common is the fibrolipoma [1, 3, 4]
Cases reporting on lipoma with osteo/chondroid differentiaion were only 16 cases as a result of retrieving literature from 1960 to 2008. Other names of this subclassification exist in literature; osteo/chondrolipoma, ossifying/osseous lipoma, lipoma with chondro/osseous metaplasia, and lipoma with cartilaginous/osseous change
Summary
Lipomas represent uncommon neoplasms of the oral cavity; only 1% to 5% of cases occur at this site [1]. Based on their histopathological features of conspicuous multiple components, lipomas can be divided into some subclasses [2, 3], and the most common is the fibrolipoma [1, 3, 4]. Cases reporting on lipoma with osteo/chondroid differentiaion were only 16 cases as a result of retrieving literature from 1960 to 2008. Other names of this subclassification exist in literature; osteo/chondrolipoma, ossifying/osseous lipoma, lipoma with chondro/osseous metaplasia, and lipoma with cartilaginous/osseous change. The obscure etiology of osseous/chondroid differentiaion led to confusion of the name
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