Abstract
Catalytic Friedel-Crafts acylation of benzene and unactivated benzenes, such as chlorobenzene and fluorobenzene, was successfully accomplished using rare earth(III) perfluorooctane sulfonates (RE(OPf) 3), RE = Sc, Y, La ∼ Lu) and perfluorooctanesulfonic acid (PfOH) as catalysts in fluorous solvents. Solutions of Yb(OPf) 3 and PfOH in perfluorodecalin (C 10F 18, cis and trans-mixture) are the most suitable catalytic system, with catalyst loading as low as 0.4%mol leading to clean, high-yielding benzoylation of a variety of unactivated benzenes. By simple separation of the fluorous phase containing only catalyst, acylation can be repeated several times.
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