Abstract
Gastric melanomas are usually metastatic, and primary is almost rare entity.
 Present case is a rare malignant melanoma of the gastric region with barely reported cases in the literature. A 65 year old male presented with pain abdomen and melena He was evaluated with relevant investigation. UGI endoscopy and PETCT shows large polypoidal irregular gastric mass in the proximal curvature extending upto gastroesophageal junction. Endoscopic biopsy a ulcero-infiltrating tumour, Individual cells are large, round, having moderately pleomorphic, hyperchromatic nuclei with prominent eosinophilic nucleoli and moderate eosinophilic cytoplasm. Immunohistochemistry of S100 and HMB45 was positive and negative for CK7 and CK20.
 Early diagnosis of primary gastric melanoma allows for better prognosis of the patient from the right intervention.
Highlights
Digestive tract melanomas are rare, typically occurs in anogenital region
Primary melanomas are considered as cutaneous neoplasm and extracutaneous presentation is very uncommon and often primary site is difficult to identify
UGI endoscopy revealed large, nodular, proliferative, ulcerated, friable fleshy growth seen in the fundus (Fig. 1)
Summary
Digestive tract melanomas are rare, typically occurs in anogenital region. Less common location involves oesophagus, stomach, intestine and gallbladder. Primary melanomas are considered as cutaneous neoplasm and extracutaneous presentation is very uncommon and often primary site is difficult to identify. The pathogenesis of primary mucosal melanoma are environmental, immune, hereditary risk factors and association with other co morbidities, with no proven concurrences [1]
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