Abstract
Abstract Colorectal cancer (CRC) ranks third in the top of the most common neoplasms in both women and men, with a high mortality rate. In the etiopathogenesis of colorectal cancer, genetic and environmental factors play an important role. In recent years, there has been a decrease in the incidence of new cases and mortality among patients over the age of 50. This can be explained by the application of modern multimodal treatment methods as well as by increasing the use of screening methods. Particular attention should be paid to inherited syndromes such as Lynch syndrome and Familial Adenomatous Polyposis, which together account for 5% of all colorectal cancers. It was found that an accumulation of genetic mutations over a period of 10 to 15 years, leads to changes in the normal colonic epithelium, with the eventual appearance of invasive carcinoma.(1,2)
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