Abstract
Colorectal cancer is the third most common cancer in both men and women. Mixed adenoneuroendocrine carcinoma is a rare subtype of colorectal cancer defined as malignant neoplasms in which each component represents at least 30% of the lesion. It was named as Mixed adenoneuroendocrine carcinoma and described by the World Health Organization in 2010. Due to its morphological heterogeneity and the rarity of the condition, it becomes quite challenging to formulate an appropriate treatment plan. In this report, we present a case of 67-year-old man found to have a rectal mixed adenoneuroendocrine carcinoma. We discussed the current management strategies and provide a review of the literature.
Highlights
Colorectal cancer is one of the most common cancers affecting both men and women [1]
There is no unifying concesus of how to manage mixed adenoneuroendocrine carcinoma, with some literature suggesting they behave in a similar pattern to more common adenocarcinomas and should be treated as such [5]
Biopsies of the circumferential mass showed solid sheets and granular architecture with tumor necrosis and desmoplasia; histostaning: synaptophysin positive for more than 50%, chromogranin positive about 1/3rd, Ki-67 showing 75-90% nuclear proliferative activity consistent with a Mixed Adenoneuroendocrine Carcinoma (Figure 3 A, B, C, D)
Summary
Colorectal cancer is one of the most common cancers affecting both men and women [1]. It causes almost 694,000 deaths in 2012 [2]. In the world of colorectal carcinoma, mixed adenoneuroendocrine carcinoma (MANEC) is exceptionally rare [3]. It consists of two clinically aggressive neoplasms with considerable morphological heterogeneity which makes it difficult to diagnose and formulate appropriate treatment plan [4]. There is no unifying concesus of how to manage mixed adenoneuroendocrine carcinoma, with some literature suggesting they behave in a similar pattern to more common adenocarcinomas and should be treated as such [5]. We present a case of 67-year-old man found to have a rectal mixed adenoneuroedocrine carcinoma
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