Abstract
We present here a case of young male with complaints of fever and swelling in the neck for eight months. History of progressive weakness associated with weight loss was present. Physical examination revealed pallor, multiple enlarged cervical lymph nodes and hepatosplenomegaly. Investigations showed pancytopenia, hyperglobinemia and Leishman-Donovan bodies on bone marrow aspiration. Serological test confirmed diagnosis of visceral leishmaniasis. However, cervical lymph node aspiration and biopsy were suggestive of Mixed cellularity Hodgkin's disease. This made it a very rare case of Leishmaniasis as an opportunistic infection in a patient of pre-chemotherapy Hodgkin's disease. There was marked improvement in haematological profile and regression of hepatosplenomegaly with Amphotericin B treatment followed by favourable response to chemotherapy. The case emphasizes the suspicion for leishmaniasis as a masquerader and as an opportunistic infection in haematological malignancies.
Highlights
We present here a case of young male with complaints of fever and swelling in the neck for eight months
Leishmaniasis is frequently reported in patients with immunocompromised states due to HIV infection, post organ transplantation, solid tumors and chemotherapy [1,2]
The case presented is a rare case of association of visceral leishmanisis and Hodgkin’s disease right from the beginning and delves into the pathological and practical implications of their coexistence [10,11]
Summary
We present here a case of young male with complaints of fever and swelling in the neck for eight months. Leishmaniasis is frequently reported in patients with immunocompromised states due to HIV infection, post organ transplantation, solid tumors and chemotherapy [1,2]. There are very few case reports of leishmaniasis with haematological malignancies, and even fewer with lymphoma, Hodgkin’s disease [3,4,5,6].
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