Abstract
Rapidly progressing glomerulonephritis in children is a rare but the most aggressive form of glomerulonephritis. This disease is clinically characterized by acute nephritic syndrome with rapidly progressive renal failure, morphologically it is characterized by the presence of extracapillary cellular or fibro-cellular crescent in more than 50% of glomeruli. Currently the literature describes only a few cases of clinical course of glomerulonephritis in children. The article presents the researchers’ observation of rapidly progressive glomerulonephritis type I (anti-BMC+) in a 12-year-old girl. Despite immunosuppressive therapy combined with plasmapheresis, the authors observed the progress of the disease resulting in chronic kidney disease stage V. The child received renal replacement therapy with peritoneal dialysis. The course was complicated by the development of severe hyperparathyroidism.
Highlights
Быстропрогрессирующий гломерулонефрит у детей – редкая, но наиболее агрессивная форма гломерулонефрита
Progressing glomerulonephritis in children is a rare but the most aggressive form of glomerulonephritis. This disease is clinically characterized by acute nephritic syndrome with rapidly progressive renal failure, morphologically it is characterized by the presence of extracapillary cellular or fibro-cellular crescent in more than 50% of glomeruli
Despite immunosuppressive therapy combined with plasmapheresis, the authors observed the progress of the disease resulting in chronic kidney disease stage V
Summary
Быстропрогрессирующий гломерулонефрит у детей – редкая, но наиболее агрессивная форма гломерулонефрита. For citation: Makarova T.P., Samoilova N.V., Soldatova E.E., Akhmadullina L.I. Rapidly progressing glomerulonephritis in children. Основными критериями служат тип свечения иммунореактанта в нефробиоптате и наличие повреждающего фактора (анти-БМК-антитела, АНЦА и иммунные комплексы) в сыворотке крови больного. Характеризуется «линейным» свечением антител при иммуногистологическом исследовании ткани почек и наличием циркулирующих анти-БМКантител в сыворотке крови.
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