Abstract
It is demonstrated that a rapidly labeled heterogeneous nuclear RNA fraction (20 to 80 s) from HeLa cell nuclei is 44% GC (similar to DNA) while as previously reported ( Scherrer, Latham & Darnell, 1963 ) the 45 s precursor to ribosomal RNA has a GC content of more than 60% (similar to rRNA). The ribosomal precursor RNA can be separated from a majority of the heterogeneous RNA by the nuclear fractionation techniques of Penman, Smith & Holtzman (1966) . An attempt is made to determine whether the relative rate of synthesis of the heterogeneous nuclear RNA exceeds that which could ultimately be found in the cell cytoplasm as messenger RNA. It appears likely that at least some of this RNA is precursor to cytoplasmic messenger RNA and it is impossible at this time to state whether or not any of this heterogeneous nuclear fraction “turns over” without ever leaving the nucleus.
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