Abstract
Developing a strongly adhesive, easily removable, and robust bandage is valuable in trauma emergencies. Poly(lipoic acid) (PLA)-based adhesives with good mechanical properties have been well-developed through a thermal ring-opening polymerization (ROP) method that is easiness. However, the additive manufacturing of PLA-based adhesives remains a challenge. Herein, α-lipoic acid (LA) and trometamol (Tris) are found to rapidly form a supramolecular hydrogel at room temperature with injectability and 3D printing potential. Meanwhile, the synthesized LA-grafted hyaluronic acid and cellulose nanocrystals are involved not only to optimize the extrusion of 3D printing but also to effectively promote fidelity and prevent the inverse closed-loop depolymerization of PLA in water. The hydrogel bandage exhibits strong adhesion to skin while it can be removed with no residue by water flushing, showing protection to neo-tissue during dressing replacement. The in vivo application of the hydrogel bandage significantly promoted wound healing by closing the wound, forming a physical barrier, and providing an anti-inflammatory effect, showing great potential in future clinical applications.
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