Abstract
Laser speckle contrast imaging has been widely used for quantifying blood perfusion. In this letter, we propose a rapid, wide-field laser speckle angiography technique for noninvasive imaging of retinal and choroidal vessels. The field of view (FOV) reaches ∼50∘ while the acquisition time was less than 1 s. Larger FOV (∼90∘) can be further improved by mosaicking. The results were comparatively studied with optical coherence tomography angiography and fundus fluorescence angiography. The low-cost technology can obtain wide-field fundus vascular and perfusion images less than 1 s. This technology is more suitable for optic disc and choroidal vasculature imaging. In addition, blood flow dynamic information such as pulsation can be provided by this technique.
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