Abstract
Spectrally encoded confocal microscopy (SECM) is a technique that allows confocal microscopy to be performed through the confines of a narrow diameter optical fiber probe. We present a novel scheme for performing SECM in which a rapid wavelength swept source is used. The system allows large field of view images to be acquired at rates up to 30 frames/second. Images of resolution targets and tissue specimens acquired ex vivo demonstrate high lateral (1.4 mum) and axial (6 mum) resolution. Imaging of human skin was performed in vivo at depths of up to 350 mum, allowing cellular and sub-cellular details to be visualized in real time.
Highlights
BoudouxHarvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital 50 Blossom Street, BAR 7, Boston, Massachusetts, 02114
Biologists have used confocal microscopy [1] for many years to observe cells and thin sections of tissue with high resolution and contrast
Spectrally encoded confocal microscopy (SECM) is a technique that allows confocal microscopy to be performed through the confines of a narrow diameter optical fiber probe
Summary
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital 50 Blossom Street, BAR 7, Boston, Massachusetts, 02114. Massachusetts Eye and Ear Infirmary Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital
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