Abstract
Adapting neural representation to rapidly changing behavioural demands is a key challenge for the nervous system. Here, we demonstrate that the output of the primary olfactory area of the mouse, the olfactory bulb, is already a target of dynamic and reproducible modulation. The modulation depends on the stimulus tuning of a given neuron, making olfactory responses more discriminable through selective amplification in a demand-specific way.
Highlights
Behavioural contexts often pose conflicting demands on neural representations of stimuli
Previous studies indicate that changes in sensory processing accompany behavioural acquisition of olfactory discrimination as early as in the primary olfactory region of the mouse, the olfactory bulb (OB)
As mice learn olfactory discrimination tasks over days, how the OB output changes during this period depends on the difficulty of the task, where the change in response decorrelation depends on the similarity of odours used (Chu et al, 2016; Yamada et al, 2017)
Summary
Behavioural contexts often pose conflicting demands on neural representations of stimuli. Previous studies indicate that changes in sensory processing accompany behavioural acquisition of olfactory discrimination as early as in the primary olfactory region of the mouse, the olfactory bulb (OB). As mice learn olfactory discrimination tasks over days, how the OB output changes during this period depends on the difficulty of the task, where the change in response decorrelation depends on the similarity of odours used (Chu et al, 2016; Yamada et al, 2017) Some of these changes may be associated with animals becoming familiar with the stimuli over days (Chu et al, 2016). Whether such task-related changes in the OB are dynamic, and how they are implemented remain unclear
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