Rapid synthesis of some medicinally important hexahydro-s-triazine derivatives incorporating benzothiazole

Abstract

A series of 2,4,6-trisubstituted 1,3,5-tris (benzothiazo l-2-yl) hexahydro-1,3,5-triazine derivatives ( 3) have been synthesized by condensation of substituted benzothiazoles with 2,4,6-trisubstituted 1,3,5-trioxane by convention al as well as microwave irradiation (solvent free and solid support) methods. All compounds were tested for antiproliferative activity and entomological activity. The microwave irradiation technique gives better yield and reaction completion in a shorter period of time. Among solid supported microwave irradiation better yields are obtained with acidic alumina as compared to silica, neutral alumina and basic alumina.The results of biological activities prompted us that change in substitution patter n in benzothiazolyltriazine derivatives may cause marked effect on their antiproliferative activity.