Abstract
Abstract1. An improved method for identification of the structure of drug metabolites by mass spectrometry is described.2. By labelling the drug with a stable isotope the metabolites can be easily identified by the isotope distribution of their fragment ions. The isolation procedure can therefore be reduced to a single 2-dimensional thin-layer chromatogram.3. Metabolism of 4-morpholino-2-piperazino-thieno[3,2-d]pyrimidine (V-K 774), labelled with 13C, was studied in the rat by this method. Significant metabolic transformations of both the piperazine and morpholine substituents were demonstrated.
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